CORDIS Project
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This project investigates the role of the calcium sensing receptor in auditory hair cells, focusing on how it influences calcium signaling during development and maturation. By silencing the CaSR gene in chick embryos, the research aims to uncover its impact on inner ear function and potential links to hearing disorder…
Hair cells of the vertebrate cochlea have the remarkable property to transduce mechanical sound waves into electrical signals at the auditory nerve fibers.
This sensory activity involves tightly regulated intracellular Ca2+ microdomains, both at the apical stereocilia level (Ca2+ influx through the mechano-sensitive channels) and the basolateral synaptic ribbon active zones (Ca2+ influx through L-type Ca2+ channels).
Intense hair cell activity, that is spontaneous during development or evoked by…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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