CORDIS Project
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This project investigates the role of the extracellular matrix and cell adhesion molecules in brain disorders. It aims to develop new treatments for conditions like anxiety disorders, schizophrenia, and Alzheimer’s by understanding how these components affect synaptic dynamics.
Brain disorders comprise a major burden for the society.
Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases.
The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics.
Furthermore, recent studies have shown that proteolytic activity may release from the ECM/CAMs cryptic ligand(s)…
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
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United Kingdom, Exeter
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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