CORDIS Project
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This project investigates how gut bacteria interact with the host's immune system, particularly in Crohn's disease. It aims to understand the spatial and functional changes in gut bacteria and their impact on inflammation, using advanced microbiology and systems biology techniques.
Over the past two decades, gut bacteria have emerged as major regulators of human health.
The focus in the field thus far has been on bacterial taxonomy, with their spatial organization and functionality largely overlooked.
Crohn’s disease (CD) vividly portrays this spatiofunctional dimension, as it features patches of gut inflammation (skip lesions) surrounded by uninflamed regions—in the same host—with a clear demarcation but unknown cause.
Our preliminary data demonstrate host-microbe functio…
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