CORDIS Project
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This project investigates the role of Factor XII in cardiovascular disorders, focusing on its dual role in coagulation and inflammation. By using genetically modified mouse models, the research aims to uncover new therapeutic targets for conditions like ischemic heart disease and hereditary angioedema.
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system.
Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system.
This system starts a cascade of procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation, and the bradykinin-producing kallikrein-kinin system, respectively.
The biochemistry of the contact system in vitro is well understood, however…
KAROLINSKA INSTITUTET
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Germany, Hamburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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