CORDIS Project
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This project studies the repair mechanisms of DNA interstrand crosslinks, which are critical for maintaining genomic stability. By using genetically modified mice, it aims to uncover the role of specific nucleases in DNA repair and their implications for diseases like Fanconi anemia.
DNA interstrand crosslinks (ICLs) are toxic lesions, which prevent the separation of strands necessary for DNA replication. ICLs arise in cells when common endogenous metabolites react with DNA and when cells are exposed to commonly used chemotherapeutic drugs, such as mitomycin-C (MMC) and cisplatin.
Defects in the repair of endogenous ICLs cause Fanconi anaemia, characterized by chromosome instability and cancer predisposition, which underscores the importance of ICL repair for human health. I…
UNIVERSITY OF DUNDEE
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