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The FAPbulous project focuses on understanding bacterial biofilms and their resistance to antibiotics, particularly in cystic fibrosis. It aims to characterize the structure and function of amyloid fibrils in Pseudomonas aeruginosa to develop new antimicrobial strategies.
Bacterial resistance to antibiotics poses a critical global threat and is partly due to the formation of stable biofilms which shield bacterial cells from antibiotics.
Cystic fibrosis in lugs and some hospital-acquired infections caused by Pseudomonas aeruginosa are closely linked to the formation of biofilms and resistance mechanisms, which include the presence of amyloid fibrils.
Amyloids are a class of proteins known for their ability to self-assemble into highly structured fibrils.
Their piv…
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