CORDIS Project
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This project focuses on understanding the folding and assembly mechanisms of a protein involved in the secretion process of Gram-negative bacteria. By studying the protein's behavior in different lipid environments, the research aims to uncover fundamental principles of membrane protein structure.
Type II secretion in Gram-negative bacteria is the general exit route for proteins that function outside the cell.
During secretion, preproteins are first translocated across the inner membrane, after which the dedicated type II secretion system transports the protein across the outer membrane.
In Klebsiella oxytoca the outer membrane pore is formed upon dodecamerisation of PulD, a founder member of the secretin superfamily.
The minimal assembly unit of PulD, comprising the transmembrane C-domai…
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