CORDIS Project
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This project investigates the interaction between DNA G-quadruplexes and synthetic ligands for potential cancer therapy. By stabilizing G-quadruplex structures in telomeric DNA, the research aims to inhibit telomerase activity, which is crucial for the immortality of cancer cells.
This proposal focuses on the formation of complex between DNA G-quadruplexes and a new family of synthetic ligands, which might be relevant for cancer therapy.
The enzymatic acitivity of telomerase is critical to the immortality of most human cancer cell lines.
However, telomeric DNA may fold into guanine quadruplex structures which are not competent substrates for telomerase.
Therefore, the use of small molecule ligands to induce quadruplex stabilisation in telomeric DNA has potential as an ant…
UNIVERSITE BORDEAUX I
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