CORDIS Project
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This project investigates common fragile sites in chromosomes, which are prone to instability and linked to cancer. Using models of Fanconi anemia, it aims to uncover the molecular events leading to chromosomal alterations and their effects on gene expression related to cell survival and proliferation.
Originally described by cytogeneticists, common fragile sites (CFSs) are chromosomal regions known for their susceptibility to break and rearrange aberrantly, thus altering the expression of genes located therein. CFS instability is associated with tumor development and pathogenic copy number variations.
Recent advances have significantly contributed to dissect the molecular bases of CFS instability, yet a unifying model for their unique breakage propensity has not been determined.
Fanconi anemi…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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