CORDIS Project
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This project investigates the role of adipose tissue as a reservoir for the Trypanosoma brucei parasite in African sleeping sickness. It aims to uncover how the parasite adapts to fat tissue and its implications for disease progression and host health.
Background:
The study of protozoan pathogens has been extensively explored often motivated to find suitable targets for new intervention strategies.
However these studies have been mostly limited to those life-cycle stages that can be cultivated in vitro.
Using a mouse model of African trypanosomiasis, we have recently discovered that the adipose tissue (fat) is a major reservoir for the extracellular protozoan Trypanosoma brucei and that, within this environment, parasites become phenotypically…
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