CORDIS Project
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This project explores the biosynthesis of natural products from cyanobacteria, focusing on fatty acids. By utilizing unique metabolic pathways, it aims to discover new compounds and enzymes that could enhance drug development and agricultural applications.
Known, but mostly novel natural products (NPs) are in high demand – these are used in drugs, cosmetics and agrochemicals and serve also as research tools to probe biological systems. NP structures inspire chemists to develop new syntheses, and NP biosynthetic enzymes add to the metabolic engineer’s toolbox.
The advent of next generation DNA-sequencing has revealed a vastly rich pool of NP biosynthetic gene clusters (BGCs) among bacterial genomes, most of which with no corresponding NP.
Hence, op…
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