CORDIS Project
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This project investigates the function and pharmacology of voltage-activated sodium channel Nav1.9, using chimaeras with potassium channels to identify interactions with pharmacological agents. The research aims to understand how lipid environments and auxiliary beta-subunits influence channel kinetics and activation.
Previously, we used voltage-activated potassium (Kv) channels as reporters to identify and examine the contributions of individual voltage-activated sodium (Nav) channel paddle motifs to the kinetics of voltage sensor activation and to toxin receptors (Bosmans et al., 2008).
Inspired by our results, we now want to deconstruct the function and pharmacology of Nav1.9, a channel of which our knowledge is very rudimentary because no pharmacological agents are available.
Furthermore, attempts to expr…
KATHOLIEKE UNIVERSITEIT LEUVEN
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