CORDIS Project
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This project focuses on understanding the mechanisms of Iron-Sulfur protein biogenesis under stress in the bacterium Escherichia coli. It aims to identify small regulatory RNAs that control this process, which is crucial for maintaining cellular integrity and preventing damage from free iron.
Iron-Sulfur (Fe-S) cofactors containing proteins are key players in a plethora of biological pathways.
Despite their essential roles, and because of the vulnerability of Fe/S cofactors, these proteins are not only highly prone to stress induced damage but also are internal “stress inducers” themselves as they can release free Fe2+ which produces toxic radicals by reacting with oxygen.
Cells have thus designed multiple intricate ways to maintain Fe-S proteins integrity and to avoid Fe-S proteins…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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