CORDIS Project
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This project focuses on understanding the role of regulatory T cells in tumors and their impact on anti-tumor immune responses. By profiling specific RNA molecules in these cells, it aims to identify potential therapeutic targets for enhancing cancer treatments.
Although tumor tissues can be infiltrated by T cells specific for tumor antigens, the effector functions of these lymphocytes are generally suppressed by CD4+ regulatory T cells (Tregs).
Since tumor infiltrating Tregs can display function heterogeneity, depending on both the tumor type and the inflammatory milieu, only inhibition of the right Treg activity should result in the unleash of an effective anti-tumor T cell responses.
Experimental plan:
To identify the Tregs that truly inhibit anti-tu…
UNIVERSITA DEGLI STUDI DI MILANO
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