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FIREALARM investigates the origins of inflammation by exploring how intercellular signaling proteins influence pyroptosis and chronic inflammatory states. The project employs advanced techniques to analyze molecular interactions and aims to develop strategies for reversing chronic conditions related to inflammation.
Inflammation is a natural mechanism to restore tissue homeostasis, and its deregulation causes human disease.
The programmed cell death form pyroptosis elicits inflammation in a cell-autonomous and non-autonomous fashion by releasing cytokines and ‘danger’ signals.
Intriguingly, immune pathology independent of cytokines has alluded to unexplored signaling circuits between cells regulating pyroptotic inflammatory reactions.FIREALARM addresses the fundamental question of the physiological origin o…
UNIVERSITATSKLINIKUM BONN
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