CORDIS Project
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This project investigates the communication between mitochondria and the nucleus, focusing on how mitochondrial dysfunction influences cellular behavior. It aims to uncover the mechanisms of metabolic regulation and develop strategies to target these pathways for therapeutic applications in conditions associated with m…
The molecular communication between mitochondria and nucleus is an integrated bi-directional crosstalk - anterograde (nucleus to mitochondria) and retrograde (mitochondria to nucleus) signalling pathways.
The mitochondrial retrograde response (MRR) is driven by defective mitochondrial function, which increases cytosolic reactive oxygen species (ROS) and Ca2+.
Metabolic reprogramming is a key feature in highly proliferative cells to meet the energy needs for rapid growth by generating substrates…
QUEEN MARY UNIVERSITY OF LONDON
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United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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