CORDIS Project
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This project investigates the role of interleukin-10 in carp, focusing on its production by leukocytes and the effects of both carp and koi herpesvirus interleukin-10 on immune responses. The research aims to understand the evolutionary conservation of this important cytokine's function across vertebrates.
Interleukin (IL)-10 is a cytokine that, at least in mammals, plays a central role in innate and adaptive immunity. IL-10 limits inflammation by acting on macrophages and promotes anti-inflammatory responses via T-helper cells.
Underlining the regulatory role of IL-10 is the presence of IL-10 homologues in viral genomes (vIL-10).IL-10 has been cloned in several fish species but only recently a vIL-10 has been identified in the genome of koi-herpes-virus (KHV), a highly pathogenic virus of carp. V…
WAGENINGEN UNIVERSITY
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