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FishTRIM investigates the evolution and function of TRIM family E3 ubiquitin ligases in fish, focusing on their role in antiviral responses and immune mechanisms against viral pathogens. The project employs advanced genetic and genomic techniques to explore the co-evolution of these ligases and viruses, aiming to enhan…
FishTRIM aims to study the evolution and function of the TRIM family of E3 ubiquitin ligases in fish.
This family has undergone several clade-specific expansions across the fish phylogeny, with single-copy mammalian TRIMs frequently present in large numbers in fish genomes. TRIM E3 ligases and their direct interactions with viral proteins are key in host-pathogen relationships, and several fish TRIMs have been associated to antiviral responses.
Additionally, positive selection has been observed…
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
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