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The FLEX5 project investigates the role of serotonin neurons in behavior and cognitive flexibility. By utilizing advanced techniques like calcium imaging and optogenetics, it aims to understand how these neurons influence responses to both aversive and rewarding stimuli.
One the most relevant neuromodulator which affect the organisms’ ability to adapt to environmental changes and to aversive events is serotonin or 5-hydroxytryptamine (5-HT). 5-HT has long and widely been implicated in the pathophysiology of several psychiatric diseases such as obsessive-compulsive disorder, anxiety, drug addiction and depression.
Emerging evidence indicate that 5-HT also plays a crucial role in cognitive and behavioral flexibility.
Serotonin neurons respond to aversive stimuli a…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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