CORDIS Project
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This project investigates the signaling mechanisms of semaphorins and their receptors, crucial for guiding cells during development and maintaining tissue health. By combining structural biology and imaging techniques, the research aims to uncover how these proteins influence cell behavior, with implications for immuno…
During the development of a multicellular organism cell guidance proteins interact with their cognate cell surface receptors to guide cells to their correct location.
Such functions continue to be essential in the adult to maintain tissue homeostasis.
Semaphorins use plexins as their main receptors for signalling and the semaphorin and plexin families together constitute one of the largest and functionally diverse of the cell guidance systems in vertebrates.
We have gained some insight into the…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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