CORDIS Project
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This project investigates the physical principles behind the formation of the blastocyst during mammalian embryogenesis. It focuses on the role of fluid cavities in tissue mechanics and cell differentiation, using advanced imaging techniques to understand how these factors influence embryonic development.
An important morphogenetic event of mammalian embryogenesis is the formation of a blastocyst with a fluid-filled cavity, blastocoel, and the establishment of three cell types essential for implantation.
Morphogenesis of the blastocyst begins with the emergence of multiple nascent cavities, which progressively coalesce to form one cavity segregating the cavity-facing primitive endoderm from the epiblast within the inner cell mass.
While cell-to-cell gene expression heterogeneity is well character…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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