CORDIS Project
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This project explores how the influenza virus escapes from host cells, focusing on the matrix protein M1's role in virus assembly and release. It utilizes in vitro models to understand the mechanisms of viral budding and membrane fission.
Enveloped viruses, such as influenza, acquire their outer lipid envelope by budding from the membrane of the infected host before being released in the extra-cellular space by membrane fission.
In these last steps of the virus infection cycle, matrix proteins connecting capsid with the lipid envelope often play a key role in assembly and budding of newly produced virions.
In spite of the widely acknowledged impact on public health and economy of influenza epidemics, the processes facilitating eg…
INSTITUT CURIE
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