CORDIS Project
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This project focuses on developing a new method for synthesizing complex molecules used in Positron Emission Tomography (PET) imaging. By utilizing late-stage fluorination, it aims to enhance the production of PET tracers, improving their availability and effectiveness in diagnosing diseases.
Positron Emission Tomography (PET) is a powerful non-invasive, real-time imaging technology that can be used to identify and characterize human disease, but is currently limited by deficiencies in chemistry.
While simple molecules can be efficiently prepared, more complex, biomedically interesting molecules often cannot.
The short half-life of [18F] (110 min) dictates severe restrictions on the chemical synthesis of PET tracers.
Fluoride introduction must occur at a late stage of the synthesis,…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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