CORDIS Project
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This project focuses on developing new catalysts for creating tetrasubstituted olefins with fluorine or polyfluoroalkyl groups, which are valuable in drug discovery. The methods aim to enhance the synthesis and modification of these compounds for improved bioactivity in pharmaceuticals.
Practical strategies that provide facile access to tetrasubstituted olefins bearing a fluorine atom and/or a polyfluoroalkyl moiety are crucial to drug discovery and development and are therefore in high demand.
Equally important and sought-after are reliable and stereocontrolled methods for modifying such alkenes.
Nonetheless, such methods are scarce, and those available are severely limited in scope.
In this context, catalytic olefin metathesis offers a unique disconnection to access modifiabl…
UNIVERSITE DE STRASBOURG
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