CORDIS Project
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This project investigates the potassium efflux system in bacteria, focusing on the activation mechanism of the Kef system. By using advanced techniques like NMR and biophysical assays, the research aims to understand how this system can be targeted for antibiotic development.
The potassium efflux system, Kef, protects bacteria against the detrimental effects of electrophilic compounds via acidification of the cytoplasm.
Its vital role in maintaining cell homeostasis makes Kef a promising target for antibiotics, but such drugs can be developed only with a molecular understanding of Kef activation.
Our work indicates that phenylalanine residue 441 (F441) in Escherichia coli is crucial for the activation of K+ efflux.
This mechanism is conserved, and F448 of Shewanella…
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