CORDIS Project
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This project focuses on developing new synthetic methods to create fluorinated nitrogen-containing heterocycles, specifically fluoropyrrolidines, which are important for the pharmaceutical and agrochemical sectors. The approach involves using silyl groups to activate alkenes for electrophilic fluorination, enabling the…
Fluorinated nitrogen-containing heterocycles are key targets for the pharma- and agrochemical industry.
Considering the poor accessibility of these compounds, we propose to explore new synthetic methodologies to access fluoropyrrolidines.
In the light of the abundant literature on electrophile-induced cyclisations, a very attractive route to access fluoro nitrogen-containing heterocycles is the electrophilic fluorocyclisation of alkenes bearing a pending nucleophilic amino group.
However, this…
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