CORDIS Project
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This project investigates the interaction between fibronectin and collagen, two critical components of the extracellular matrix. By employing advanced biophysical techniques, the research aims to clarify their binding mechanisms and implications for biological processes such as wound healing.
Fibronectin (FN) and collagen are two members of the extracellular matrix that play important roles in embryogenesis, cell migration and adhesion, as well as in wound healing.
They act together to control fibroblast migration, collagen crosslinking and the removal of damaged tissue.
However, despite the apparent biological importance, details on the interaction of FN and collagen remain unclear.
Substantial uncertainty exists regarding the number of FN binding sites on different collagen types,…
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