CORDIS Project
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This project focuses on understanding the molecular mechanisms of focal adhesion formation, which are crucial for cell signaling and behavior. Using advanced techniques, it aims to elucidate how these complexes assemble and function in cells.
Focal adhesions (FA) are gigantic protein complexes whose formation is triggered by integrin ligand activation. FAs represent (1) a sensing platform and anchoring points to the outside environment and, (2) a machinery to transduce this information by initiating signaling pathways for cell growth, survival, migration and polarization.
Failure in the regulation of FA leads to developmental defects and contributes to the formation of aggressive cancers.
Hence, understanding FA formation is the basi…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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