CORDIS Project
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This project focuses on developing methods to create organofluorine compounds, specifically those with trifluoromethyl groups, using a technique called lithiation-borylation. The aim is to enhance the synthesis of complex molecules for medicinal chemistry by enabling the selective incorporation of fluorinated groups in…
Organofluorine compounds are highly sought after owing to diverse and numerous applications that take advantage of the unique properties imparted by the presence of one or more C–F bonds.
The chemical stability and conformational landscape of molecules, together with the small size of the fluorine atom, has the made the replacement of a C–H or C–OH bond with a C–F one of the most rewarding modifications during the hit-to-lead stage in medicinal chemistry programs.
Because many applications are d…
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