CORDIS Project
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This research explores how enzymes utilize mechanical strain during their function. By developing new sensors and molecular springs, the project aims to measure force-dependent changes in enzyme activity, enhancing our understanding of enzyme mechanisms and potentially informing enzyme design.
A fundamental but unexplored problem in biology is whether and how enzymes use mechanical strain during their functioning.
It is now evident that the knowledge of atomic structures and chemical interactions is not sufficient to understand the intricate mechanisms underlying enzyme specificity and efficiency.
Several lines of evidence suggest that mechanical effects play crucial roles in enzyme activity.
Therefore we aim to create detailed force maps that reveal how the intramolecular distributio…
EOTVOS LORAND TUDOMANYEGYETEM
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