CORDIS Project
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This project investigates the role of the beta3 adrenoceptor in heart remodeling under stress. It explores how this receptor can protect cardiac myocytes from hypertrophy through nitric oxide signaling, aiming to identify new therapeutic strategies for heart conditions.
This project investigates the role of the beta3 adrenoceptor (β3-AR) in modulating the remodeling of the myocardium submitted to stress.
Promising advances have been made in the host laboratory in showing that overexpression of the β3-AR in cardiac myocytes confers protection from pro-hypertrophic stimulus induced-remodeling.
Preliminary data suggest that nitric oxide (NO) production by NO synthase (NOS), which is known to be coupled to the β3-AR signalling in the heart, is necessary for this pr…
UNIVERSITE CATHOLIQUE DE LOUVAIN
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