CORDIS Project
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This project investigates the role of telomeres in cancer and aging. It aims to understand how genetic and epigenetic factors regulate telomere length and their implications for stem cell behavior.
Telomeres are ribonucleoprotein complexes at the ends of chromosomes that are essential for chromosome protection and genomic stability.
Telomeres consist of tandem TTAGGG repeats bound to a 6-protein complex known as shelterin.
More recently, telomeres have been also shown to contain long non-coding telomeric RNAs (TelRNAs or TERRAs), which are associated to the telomeric chromatin and have been proposed to be potential regulators of telomerase activity and telomere length.
In addition, telomer…
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