CORDIS Project
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The project investigates the role of clusterin, a glycoprotein linked to cancer, in immune suppression. It aims to understand how its specific forms may help tumors evade immune responses, potentially leading to new cancer treatment strategies.
Clusterin (CLU) is a ubiquitous glycoprotein that function as an extracellular chaperone, binding to apoptotic cells and stressed-proteins and preventing the generation of insoluble aggregates.
Although CLU is overexpressed in many type of cancers and associated with bad prognosis, the nature of this association remains obscure.
It has been previously discovered an isoform of CLU present in seminal plasma that bears fucosylated glycans that confers the ability to bind to DC-SIGN; an endocytic C-…
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