CORDIS Project
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This project investigates the evolutionary mechanisms behind gene duplication and functional differentiation, focusing on flavoprotein disulfide reductases. It aims to understand their role in metabolism and potential applications in biotechnology through directed evolution.
Gene duplication followed by sequence divergence is recognized as a key mechanism in evolution to generate functional innovations and enrich the complexity of genetic networks.
Though gene duplication is frequently observed, the ensuing process leading to functional differentiation among gene duplicates remains obscure.
Lack of this critical information has limited not just our fundamental understanding of protein evolution, but the success in engineering enzymes for industrial applications and…
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