CORDIS Project
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This research focuses on the role of specific proteins in regulating cell junctions during the development of epithelial tissues in Drosophila. It aims to uncover the molecular mechanisms by which these proteins influence cell growth and organization.
Src-family kinases play major roles in promoting adherens junctions remodelling in development and metastasis.
Their activities are negatively regulated by C-terminal Src kinase (Csk).
The host lab it has recently shown that Drosophila Ankyrin-repeat, SH3-domain and Proline-rich-region containing (dASPP), together with Boa the homology of mammalian Ras association domain family 8, regulates the function of dCsk in maintaining adherens junctions polarity and integrity in Drosophila (Langton et al…
CANCER RESEARCH UK LBG
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