CORDIS Project
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This project investigates the role of the CCBE1 protein in lymphatic development and its implications in congenital diseases like Hennekam syndrome. It employs zebrafish and mouse models to explore CCBE1's interactions and functions in lymphangiogenesis.
Ccbe1 has recently been identified as an essential regulator of lymphangiogenesis in zebrafish.
Loss of function of this secreted factor leads to a failure of lymphangioblast budding and a complete lack of lymphatics.
Intriguingly, mutations in human CCBE1 are causative for a congenital lymphatic malformation disease, termed Hennekam syndrome (HS).
The main goal of this project is to understand the function of Ccbe1 in development and disease.
Firstly, since the mode of action of Ccbe1 is comple…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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