CORDIS Project
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This project investigates the intrinsic repair mechanisms of articular cartilage to better understand osteoarthritis. It focuses on the role of TGF-beta activation in maintaining cartilage health under mechanical stress and aims to uncover potential treatment strategies for joint degeneration.
Articular cartilage serves as a load bearing material for synovial joints, transmitting loads while maintaining low friction and wear.
Progressive degeneration of the tissue leads to osteoarthritis (OA), a debilitating condition characterized by pain and severe limitations in mobility. OA is highly prevalent amongst the EU population and is associated with significant economic burdens.
An improved understanding of the underlying mechanisms that defeat normal tissue maintenance and lead to joint…
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