CORDIS Project
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This project aims to understand how the spatial organization of the genome within the nucleus affects gene expression. It investigates the role of chromatin positioning in transcriptional regulation and its implications for aging and disease.
DNA sequence and epigenetic chromatin maps are important in understanding how genomes are regulated.
However, these maps are linear and do not account for the three-dimensional context within which the genome functions in the cell.
The spatial organisation of the genome in the nucleus is not random and is conserved in evolution, implying that it is under functional selection.
This proposal aims to determine the functional significance of positioning specific genome regions at the edge of the nuc…
THE UNIVERSITY OF EDINBURGH
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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