CORDIS Project
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This project investigates antifungal tolerance, a poorly understood phenomenon that contributes to treatment failures. By analyzing over 1000 fungal isolates, it aims to identify the biological mechanisms behind tolerance and develop strategies to target it, potentially improving antifungal therapies.
Mortality from invasive fungal infections approaches 50%, despite the use of available antifungal drugs.
While bacterial studies have focused on drug resistance, the rare appearance of antifungal drug resistance does not explain these treatment failures.
Antifungal tolerance is a poorly understood property that is expressed to different degrees in different non-resistant isolates, yet has not been measured routinely in the clinic or in most research studies.
We do not know how tolerance differs…
TEL AVIV UNIVERSITY
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CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany, Berlin
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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