CORDIS Project
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This project investigates pediatric sarcomas, focusing on their unique genetic characteristics. By developing mouse models, it aims to identify the cells of origin and the role of oncofusion proteins in tumor maintenance, enhancing understanding of these complex cancers.
Sarcomas are an extremely heterogeneous group of mesenchymal cancers, many of which remain lethal despite decades of clinical trials. A unifying characteristic in pediatric sarcomas is their low mutational burden.
Instead, they frequently harbor an entity-specific chromosomal rearrangement giving rise to an oncofusion protein that acts as the disease driver.
This genetic simplicity underlying a complex group of tumors implies a synergy between oncofusions and the cellular context in which they o…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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