CORDIS Project
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This project focuses on the role of G-quadruplexes in post-transcriptional regulation of gene expression. By identifying mRNAs affected by these structures, it aims to uncover their impact on cellular functions and potential links to diseases, paving the way for new therapeutic strategies.
Many studies of global gene expression focus solely on studying the transcriptome thereby only assessing mRNA abundance.
However, transcription is only a single layer of gene expression and recently, the influence of post-transcriptional regulation has become undeniable.
Rather underrepresented players in post-transcriptional control are G-quadruplexes (G4s).
These stable structures can form guanine tetrads in DNA and RNA via p-p-stacking of several planar arrangements of four guanine bases stab…
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