CORDIS Project
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This research investigates G-quadruplex structures in DNA and RNA, focusing on their role in genome stability and cellular processes. By identifying proteins involved in G4 formation and regulation, it aims to enhance understanding of their implications in cancer and meiosis.
Secondary structures such as G-quadruplexes (G4s) can form within DNA or RNA.
They pose a dramatic risk for genome stability, because due to their stability they can block DNA replication and this could lead to DNA breaks.
In certain cancer cells mutations/deletions are observed at G4s, if a helicase that is important for G4 unwinding is mutated.
Nevertheless, G4s are also discussed to be functional elements for cellular processes such as telomere protection, transcription, replication, and meio…
UNIVERSITATSKLINIKUM BONN
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Germany, Wuerzburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
Netherlands, Groningen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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