CORDIS Project
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This project explores the role of GABAergic neurons in brain development, particularly their function as hub cells that synchronize neuronal activity. It aims to translate findings from laboratory studies to real-life brain network dynamics in living mice.
Because of its function in brain wiring and in the generation of early correlated activity patterns, the maturation of GABAergic transmission plays a key role in enabling brain complexity in higher mammals.
Indeed, disruption of GABAergic circuitry at several time points can contribute to the generation of developmental disorders such as schizophrenia, autism or epilepsy (Le Maguerise and Moyner, 2013).
Both in the murine hippocampus and neocortex, GABAergic interneurons have been shown to parti…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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