CORDIS Project
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The GAP project aims to control axon navigation in the central nervous system by engineering neurons with magnetic switches. This technology seeks to guide axon growth and reinnervation, potentially addressing challenges in neural repair after injury.
Axon navigation is guided by spatial patterns of chemical and physical cues in the developing brain.
After a damage, the pattern is lost.
Axons do not have instructions to reach their target.
Axon regeneration, if stimulated, occurs by chance.
Unfortunately, current technologies do not allow us to control axon navigation decisions, and guided re-innervation is not possible in the central nervous system (CNS).
The GAP project aims to fill this knowledge gap by modulating neuron mechanotransductio…
UNIVERSITA DI PISA
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