CORDIS Project
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This project aims to understand the molecular mechanisms of positive allosteric modulators on neuronal nicotinic receptors. By studying these receptors, it seeks to inform the development of new treatments for conditions like nicotine addiction and Alzheimer's disease.
Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons.
These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine.
In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimer’s disease.
The current pro…
INSTITUT PASTEUR
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