CORDIS Project
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This project focuses on developing advanced models of glioblastoma and the blood-tumor barrier to improve drug delivery. By integrating glioblastoma stem cells and dynamic blood flow simulations, the research aims to enhance personalized cancer therapies and address treatment resistance in patients.
Glioblastoma (GBM) remains the most common malignant primary brain tumour with a median survival <2 years.
One of the reasons for the failure of GBM therapy involves limited drug access to the tumour site due to the presence of the blood-brain barrier (BBB)/blood-tumour barrier (BTB).
Although these barriers differ, they share some common features, such as tight junction (TJ) and efflux proteins of the ATP-binding (ABC) cassette superfamily that regulate drug access to the brain parenchyma.
Simi…
UNIVERSITA DEGLI STUDI DI TORINO
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