CORDIS Project
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This project investigates the role of goblet cells in the gut, focusing on how inflammation, genetics, and antibiotics impact their function. By using a novel mouse model, the research aims to understand goblet cell behavior during inflammatory bowel diseases and explore potential therapeutic targets.
Goblet cells are specialized epithelial cells that secrete mucus and antimicrobial proteins which together form the gut mucus barrier.
The mucus barrier protects the host from bacterial invasion and subsequent activation of an inflammatory response, while also providing food for the microbiome.
Dysfunction of goblet cells and high penetrability of the mucus barrier are hallmarks of inflammatory bowel diseases (IBD).
While the reasons for goblet cell dysfunction are unclear, it is thought that in…
BAR ILAN UNIVERSITY
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