CORDIS Project
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This project explores the role of reproductive hormones in glucose metabolism during pregnancy, particularly in women at risk for gestational diabetes. It aims to understand how hormonal changes affect insulin sensitivity and metabolic health.
Normal gestation is associated with substantial changes in maternal metabolism including a marked increase in insulin resistance and mild cholestasis, hypercholesterolaemia, and hypertriglyceridemia at later gestational weeks.
In some predisposed women, the metabolic changes are adequately severe to lead to development of gestational disorders of pregnancy including gestational diabetes mellitus (GDM) and intrahepatic cholestasis of pregnancy (ICP).
Indeed, women with ICP are more susceptible to…
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