CORDIS Project
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This project investigates how embryonic polarity is established in higher vertebrates, focusing on gene interactions and mechanisms of embryonic regulation. It aims to create a mathematical model of early development to predict outcomes related to embryonic growth and twinning.
Much of what we know about how embryos determine their axes of symmetry comes from research in invertebrates (mainly Drosophila) and cold-blooded vertebrates (mainly Xenopus).
In both cases, polarity is set up by the localisation of maternal determinants in the cytoplasm of the fertilised egg.
These determinants are inherited differentially by daughter cells, leading them to acquire different fates, which effectively fixes the axes of the embryo by the 8 cell stage.
In contrast, in amniotes (rep…
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