CORDIS Project
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This project explores how DNA binding proteins influence chromatin structure and epigenetic regulation during development. It aims to identify novel proteins that affect DNA methylation patterns and higher-order chromosome structures, enhancing our understanding of genome biology.
Decoding of the genome during development and differentiation depends on sequence-specific DNA binding proteins that regulate transcription.
The activity of transcription factors is constrained, however, by chromatin structure and by modification of histones and DNA, known collectively as the “epigenome”.
Diseased states, particularly cancers, are often accompanied by epigenomic disturbances that contribute to aetiology, but despite much research the molecular determinants of chromatin and DNA m…
THE UNIVERSITY OF EDINBURGH
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